Neurovascular Coupling in the Dentate Gyrus Regulates Adult Hippocampal Neurogenesis.

ABSTRACT: Newborn dentate granule cells (DGCs) are continuously generated in the adult brain. The mechanism underlying how the adult brain governs hippocampal neurogenesis remains poorly understood. In this study, we investigated how coupling of pre-existing neurons to the cerebrovascular system regulates hippocampal neurogenesis. Using a new in vivo imaging method in freely moving mice, we found that hippocampus-engaged behaviors, such as exploration in a novel environment, rapidly increased microvascular blood-flow velocity in the dentate gyrus. Importantly, blocking this exploration-elevated blood flow dampened experience-induced hippocampal neurogenesis. By imaging the neurovascular niche in combination with chemogenetic manipulation, we revealed that pre-existing DGCs actively regulated microva

SUBMITTER: Shen J 

PROVIDER: S-EPMC6728189 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature