Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion.

ABSTRACT: P21-activated kinase-1 (PAK-1) is a serine/threonine kinase involved in multiple signaling pathways that mediate cellular functions such as cytoskeletal motility, cell proliferation, and survival. PAK-1 expression is altered in various cancers, including prostate and breast. Our recent studies showed that prostate cancer cells expressing higher levels of PAK-1 were resistant to the cytotoxic effects of the PAK-1 inhibitor, inhibitor targeting PAK-1 activation-3 (IPA-3), compared to those with lower expression. This study expanded these findings to other cancers (breast and melanoma) by testing the hypothesis that genetic and pharmacological inhibition of PAK-1 alters cell growth, migration, and invasion in prostate, breast, and skin cancer cell lines. We also tested the specificity of IPA-

SUBMITTER: Najahi-Missaoui W 

PROVIDER: S-EPMC6728842 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature