Drug repurposing for Alzheimer's disease based on transcriptional profiling of human iPSC-derived cortical neurons.

ABSTRACT: Alzheimer's disease is a complex disorder encompassing multiple pathological features with associated genetic and molecular culprits. However, target-based therapeutic strategies have so far proved ineffective. The aim of this study is to develop a methodology harnessing the transcriptional changes associated with Alzheimer's disease to develop a high content quantitative disease phenotype that can be used to repurpose existing drugs. Firstly, the Alzheimer's disease gene expression landscape covering severe disease stage, early pathology progression, cognitive decline and animal models of the disease has been defined and used to select a set of 153 drugs tending to oppose disease-associated changes in the context of immortalised human cancer cell lines. The selected compounds have then be

SUBMITTER: Williams G 

PROVIDER: S-EPMC6731247 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature