High maternal early-pregnancy blood glucose levels are associated with altered fetal growth and increased risk of adverse birth outcomes.

ABSTRACT:

Aims/hypothesis

The study aimed to assess the associations of maternal early-pregnancy blood glucose levels with fetal growth throughout pregnancy and the risks of adverse birth outcomes.

Methods

In a population-based prospective cohort study among 6116 pregnant women, maternal non-fasting glucose levels were measured in blood plasma at a median 13.2 weeks of gestation (95% range 9.6-17.6). We measured fetal growth by ultrasound in each pregnancy period. We obtained information about birth outcomes from medical records and maternal sociodemographic and lifestyle factors from questionnaires.

Results

Higher maternal early-pregnancy non-fasting glucose levels were associated with altered fetal growth patterns, characterised by decreased fetal growth rates in mid-pregnanc

SUBMITTER: Geurtsen ML 

PROVIDER: S-EPMC6731335 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature