Plasma levels of apolipoprotein E, APOE genotype, and all-cause and cause-specific mortality in 105 949 individuals from a white general population cohort.

ABSTRACT:

Aims

To determine whether plasma apoE levels and APOE genotype are associated with all-cause and cause-specific mortality.

Methods and results

Using a prospective cohort design with 105 949 white individuals from the general population, we tested the association between plasma apoE at study enrolment and death during follow-up, and whether this was independent of APOE genotype. We confirmed the well-known association between APOE genotypes and mortality. For all-cause, cardiovascular, and cancer mortality, high levels of apoE were associated with increased risk, while for dementia-associated mortality low levels were associated with increased risk. For the highest vs. the fifth septile of plasma apoE, hazard ratios (HRs) were 1.20 (95% confidence interval 1.12-1.28) for all-

SUBMITTER: Rasmussen KL 

PROVIDER: S-EPMC6735871 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature