Intravenous esomeprazole 40 mg vs. intravenous lansoprazole 30 mg for controlling intragastric acidity in healthy adults.

ABSTRACT:

Background

Intravenous (IV) formulations of proton pump inhibitors are effective for patients in whom oral therapy is not appropriate.

Aim

To compare IV esomeprazole and IV lansoprazole for the control of intragastric pH.

Methods

In this open-label crossover study, healthy, Helicobacter pylori-negative adults were randomized to one of two treatment sequences, each consisting of two 5-day dosing periods of IV esomeprazole 40 mg or IV lansoprazole 30 mg. Twenty-four-hour intragastric pH monitoring was conducted on days 1 and 5 of each dosing period.

Results

On days 1 and 5, intragastric pH was >4.0 significantly longer with esomeprazole than lansoprazole (least-squares means: day 1, 40.0% vs. 33.6%; day 5, 61.9% vs. 45.4%; both P < 0.0001). During the first 4 h o

SUBMITTER: Pisegna JR 

PROVIDER: S-EPMC6736538 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature