LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.

ABSTRACT:

Background

There is an increasing concern about age-related frailty because of the growing number of elderly people in the general population. The Longevity-Associated Variant (LAV) of the human BPIFB4 gene was found to correct endothelial dysfunction, one of the mechanisms underlying frailty, in aging mice whereas the RV-BPIFB4 variant induced opposite effects. Thus, we newly hypothesize that, besides being associated with life expectancy, BPIFB4 polymorphisms can predict frailty.Aim and Results: Here we investigated if the BPIFB4 haplotypes, LAV, wild-type (WT) and RV, differentially associate with frailty in a cohort of 237 elderly subjects from Calabria region in Southern Italy. Moreover, we studied the effect of systemic adeno-associated viral vector-media

SUBMITTER: Malavolta M 

PROVIDER: S-EPMC6738439 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature