The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape.

ABSTRACT: Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue development and homeostasis^1-4. They are also implicated in human developmental disorders and cancers^5-8, supporting the critical role of DNA methylation in the specification and maintenance of cell fate. Previous studies have suggested that post-translational modifications of histones are involved in specifying patterns of DNA methyltransferase localization and DNA methylation at promoters and actively transcribed gene bodies^9-11. However, the mechanisms that control the establishment and maintenance of intergenic DNA methylation remain poorly understood. Tatton-Brown-Rahman syndrome (TBRS) is a c

SUBMITTER: Weinberg DN 

PROVIDER: S-EPMC6742567 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature