Ontology highlight
ABSTRACT:
SUBMITTER: Park HJ
PROVIDER: S-EPMC6742643 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190912 1
Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α4 (GSTA4), a member of the Phase II detoxifying enzyme superfamily, mediates reduction of cisplatin ototoxicity by removing 4-hydroxynonenal (4-HNE) in the inner ears of female mice. Under cisplatin treatment, loss of Gsta4 results in more profound hearing loss in female mice compared to ma ...[more]