Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI.

ABSTRACT:

Objective

To determine the long-term association of hemoglobin levels and anemia with risk of dementia, and explore underlying substrates on brain MRI in the general population.

Methods

Serum hemoglobin was measured in 12,305 participants without dementia of the population-based Rotterdam Study (mean age 64.6 years, 57.7% women). We determined risk of dementia and Alzheimer disease (AD) (until 2016) in relation to hemoglobin and anemia. Among 5,267 participants without dementia with brain MRI, we assessed hemoglobin in relation to vascular brain disease, structural connectivity, and global cerebral perfusion.

Results

During a mean follow-up of 12.1 years, 1,520 individuals developed dementia, 1,194 of whom had AD. We observed a U-shaped association between hemoglobin

SUBMITTER: Wolters FJ 

PROVIDER: S-EPMC6745727 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature