Ontology highlight
ABSTRACT:
SUBMITTER: Xiong Y
PROVIDER: S-EPMC6748082 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Xiong Yu Y Li Linli L Zhang Liting L Cui Yangyang Y Wu Chengyong C Li Hui H Chen Kai K Yang Qiuyuan Q Xiang Rong R Hu Yiguo Y Huang Shile S Wei Yuquan Y Yang Shengyong S
Cell death and differentiation 20190115 10
Necroptosis is a programmed form of necrotic cell death, which is tightly regulated by the necroptotic signaling pathway containing receptor-interacting protein (RIP)1, RIP3, and mixed-lineage kinase domain-like (MLKL) protein. In addition to the RIP1-RIP3-MLKL axis, other factors regulating necroptosis are still largely unknown. Here a cell-based small-molecule screening led to the finding that BET inhibitors protected cells from necroptosis in the TNFα/Smac-mimetic/Z-VAD-FMK (TSZ)-induced cell ...[more]