PLZF-expressing CD4 T cells show the characteristics of terminally differentiated effector memory CD4 T cells in humans.

ABSTRACT: We show the presence of lymphoid tissue-resident PLZF⁺ CD45RA⁺ RO⁺ CD4 T cells in humans. They express HLA-DR, granzyme B, and perforin and are low on CCR7 like terminally differentiated effector memory (Temra) cells and are likely generated from effector T cells (Te) or from central (Tcm) or effector (Tem) memory T (Tcm) cells during immune responses. Tn, Naïve T cells.

SUBMITTER: Kim YH 

PROVIDER: S-EPMC6748641 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature