Mechanobiology of bone remodeling and fracture healing in the aged organism.

ABSTRACT: Bone can adapt to changing load demands by mechanically regulated bone remodeling. Osteocytes, osteoblasts, and mesenchymal stem cells are mechanosensitive and respond to mechanical signals through the activation of specific molecular signaling pathways. The process of bone regeneration after fracture is similarly and highly regulated by the biomechanical environment at the fracture site. Depending on the tissue strains, mesenchymal cells differentiate into fibroblasts, chondrocytes, or osteoblasts, determining the course and the success of healing. In the aged organism, mechanotransduction in both intact and fractured bones may be altered due to changed hormone levels and expression of growth factors and other signaling molecules. It is proposed that altered mechanotransduction may contri

SUBMITTER: Haffner-Luntzer M 

PROVIDER: S-EPMC6753991 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature