IL-17 Inversely Correlated with IL-10 via the STAT3 Gene in Pneumocystis-Infected Mice.

ABSTRACT:

Background

Pneumocystis pneumonia (PCP) remains a common opportunistic infection in immunosuppressed individuals. Current studies showed that multiple immune cells and cytokines took part in the host defense against Pneumocystis (PC). However, the roles of IL-17 and IL-10 in the development of PCP have not been elucidated.

Methods

IL-10 and IL-17 levels in serum from PCP mice were detected via ELISA. The percentages of B10 cells, IL-10⁺ macrophages, and IL-10⁺ T cells in the lung from IL-17^-/- PCP mice and Th17 cells and IL-17⁺ γδT cells in IL-10^-/- PCP mice were examined via flow cytometry. Also, antibody neutralization examination was also performed to elucidate the relationship of IL-17 and IL-10

SUBMITTER: Rong HM 

PROVIDER: S-EPMC6754930 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature