ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development.

ABSTRACT: Development and maintenance of healthy stratified epithelia require the coordination of complex transcriptional programmes. The transcription factor p63, a member of the p53 family, plays a crucial role in epithelial development and homeostasis. Analysis of the p63-dependent transcriptome indicated that one important aspect of p63 functions in epithelial development is the regulation of cell-cell and cell-matrix adhesion programmes. However, limited knowledge exists on the relevant cell-cell adhesion molecules involved in physiological epithelial formation. Similarly, limited data are available to understand if deregulation of the cell-cell adhesion programme is important in tumour formation. Here, using the epidermis as an experimental model with the RNA sequencing approach, we identify a

SUBMITTER: Smirnov A 

PROVIDER: S-EPMC6755960 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature