Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumors.

ABSTRACT: The molecular mechanisms leading to aryl hydrocarbon receptor interacting protein (AIP) mutation-induced aggressive, young-onset growth hormone-secreting pituitary tumors are not fully understood. In this study, we have identified that AIP-mutation-positive tumors are infiltrated by a large number of macrophages compared to sporadic tumors. Tissue from pituitary-specific Aip-knockout (Aip^Flox/Flox;Hesx1^Cre/+) mice recapitulated this phenotype. Our human pituitary tumor transcriptome data revealed the "epithelial-to-mesenchymal transition (EMT) pathway" as one of the most significantly altered pathways in AIPpos tumors. Our in vitro data suggest that bone marrow-derived macrophage-conditioned media induces more prominent EMT-like phenotype and enhanced migratory and in

SUBMITTER: Barry S 

PROVIDER: S-EPMC6755983 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature