Coproduction Of MCR-9 And NDM-1 By Colistin-Resistant Enterobacter hormaechei Isolated From Bloodstream Infection.

ABSTRACT:

Background

Colistin acts as the last line of defense against severe infections caused by carbapenem-resistant Enterobacteriaceae. Infections caused by extensively drug-resistant isolates coproducing MCR and carbapenemases have posed a serious public health concern.

Purpose

In this study, we reported the first clinical colistin and carbapenem-resistant Enterobacter hormaechei isolate SCNJ07 coharboring bla _NDM-1 and mcr-9 from a patient with bloodstream infection in China.

Methods

Bacterial antimicrobial susceptibility testing was performed using the broth microdilution method. Conjugation assay was carried out to investigate the transferability of mcr-9 and bla _NDM-1. Whole-genome sequencing of strain SCN

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC6756836 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature