Epigenetics and Depression: An Update.

ABSTRACT:

Objective

Depression is associated with various environmental risk factors such as stress, childhood maltreatment experiences, and stressful life events. Current approaches to assess the pathophysiology of depression, such as epigenetics and gene-environment (GxE) interactions, have been widely leveraged to determine plausible markers, genes, and variants for the risk of developing depression.

Methods

We focus on the most recent developments for genomic research in epigenetics and GxE interactions.

Results

In this review, we first survey a variety of association studies regarding depression with consideration of GxE interactions. We then illustrate evidence of epigenetic mechanisms such as DNA methylation, microRNAs, and histone modifications to influence depression i

SUBMITTER: Lin E 

PROVIDER: S-EPMC6761788 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature