Dataset Information
Epigenetics and Depression: An Update.
Ontology highlight
ABSTRACT: Objective
Depression is associated with various environmental risk factors such as stress, childhood maltreatment experiences, and stressful life events. Current approaches to assess the pathophysiology of depression, such as epigenetics and gene-environment (GxE) interactions, have been widely leveraged to determine plausible markers, genes, and variants for the risk of developing depression.Methods
We focus on the most recent developments for genomic research in epigenetics and GxE interactions.Results
In this review, we first survey a variety of association studies regarding depression with consideration of GxE interactions. We then illustrate evidence of epigenetic mechanisms such as DNA methylation, microRNAs, and histone modifications to influence depression in terms of animal models and human studies. Finally, we highlight their limitations and future directions.Conclusion
In light of emerging technologies in artificial intelligence and machine learning, future research in epigenetics and GxE interactions promises to achieve novel innovations that may lead to disease prevention and future potential therapeutic treatments for depression.
SUBMITTER: Lin E
PROVIDER: S-EPMC6761788 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Epigenetics and Depression: An Update.
Psychiatry investigation 20190829 9
<h4>Objective</h4>Depression is associated with various environmental risk factors such as stress, childhood maltreatment experiences, and stressful life events. Current approaches to assess the pathophysiology of depression, such as epigenetics and gene-environment (GxE) interactions, have been widely leveraged to determine plausible markers, genes, and variants for the risk of developing depression.<h4>Methods</h4>We focus on the most recent developments for genomic research in epigenetics and ...[more]