RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Objective

Fatty liver is a rising global health concern, significantly increasing the burden of health care cost. Nonalcoholic fatty liver disease (NAFLD) has a correlation with metabolic syndrome and its complications.

Method

We reviewed the literature regarding the mechanisms of developing NAFLD through AGE-RAGE signaling.

Results

NAFLD, metabolic syndrome, and production of advanced glycation end-products (AGEs) share many common risk factors and appear to be connected. AGE induces production of the receptor for AGE (RAGE). AGE-RAGE interaction contributes to fat accumulation in the liver leading to inflammation, fibrosis, insulin resistance, and other complications of the fatty liver disease. The immune system, especially macrophages, has an important defense mech

SUBMITTER: Asadipooya K 

PROVIDER: S-EPMC6766674 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature