The Aristotle Classifier: Using the Whole Glycomic Profile To Indicate a Disease State.

ABSTRACT: "The totality is not, as it were, a mere heap, but the whole is something besides the parts."-Aristotle. We built a classifier that uses the totality of the glycomic profile, not restricted to a few glycoforms, to differentiate samples from two different sources. This approach, which relies on using thousands of features, is a radical departure from current strategies, where most of the glycomic profile is ignored in favor of selecting a few features, or even a single feature, meant to capture the differences in sample types. The classifier can be used to differentiate the source of the material; applicable sources may be different species of animals, different protein production methods, or, most importantly, different biological states (disease vs healthy). The classifier can be used on

SUBMITTER: Hua D 

PROVIDER: S-EPMC6768561 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature