Arachidonic Acid Kills Staphylococcus aureus through a Lipid Peroxidation Mechanism.

ABSTRACT: Staphylococcus aureus infects every niche of the human host. In response to microbial infection, vertebrates have an arsenal of antimicrobial compounds that inhibit bacterial growth or kill bacterial cells. One class of antimicrobial compounds consists of polyunsaturated fatty acids, which are highly abundant in eukaryotes and encountered by S. aureus at the host-pathogen interface. Arachidonic acid (AA) is one of the most abundant polyunsaturated fatty acids in vertebrates and is released in large amounts during the oxidative burst. Most of the released AA is converted to bioactive signaling molecules, but, independently of its role in inflammatory signaling, AA is toxic to S. aureus Here, we report that AA kills S. aureus through a lipid peroxidation mechanism

SUBMITTER: Beavers WN 

PROVIDER: S-EPMC6775451 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature