The voltage-gated sodium channel Na_v1.7 associated with endometrial cancer.

ABSTRACT: Background: Endometrial cancer is the most common gynecologic malignancy in women in the developed countries. Despite recent progress in functional characterization of voltage-gated sodium channel (Na_v) in multiple cancers, very little was known about the expression of Na_v in human endometrial cancer. The present study sought to determine the role of Na_v and molecular nature of this channel in the endometrial cancer. Methods: PCR approach was introduced to determine expression level of Na_v subunits in endometrial cancer specimens. Pharmacological agents were used to investigate Na_v function in endometrial cancer cells. Flow cytometry were used to test cancer apoptosis, and invasion assays were applied to test tumor metast

SUBMITTER: Liu J 

PROVIDER: S-EPMC6775510 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature