Ontology highlight
ABSTRACT:
SUBMITTER: Blohmke CJ
PROVIDER: S-EPMC6783646 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
EMBO molecular medicine 20190830 10
Misdiagnosis of enteric fever is a major global health problem, resulting in patient mismanagement, antimicrobial misuse and inaccurate disease burden estimates. Applying a machine learning algorithm to host gene expression profiles, we identified a diagnostic signature, which could distinguish culture-confirmed enteric fever cases from other febrile illnesses (area under receiver operating characteristic curve > 95%). Applying this signature to a culture-negative suspected enteric fever cohort ...[more]