An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings.

ABSTRACT: The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing research into the DMN has taken a corticocentric approach. Despite its resemblance with the unitary model of the limbic system, the contribution of subcortical structures to the DMN may be underappreciated. Here, we propose a more comprehensive neuroanatomical model of the DMN including subcortical structures such as the basal forebrain, cholinergic nuclei, anterior and mediodorsal thalamic nuclei. Additionally, tractography of diffusion-weighted imaging was employed to explore the structural connectivity, which revealed that the thalamus and basal forebrain are of central importance for the functioning of the DMN. The contribution

SUBMITTER: Alves PN 

PROVIDER: S-EPMC6787009 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature