How structural subtleties lead to molecular diversity for the type III polyketide synthases.

ABSTRACT: Type III polyketide synthases (PKSs) produce an incredibly diverse group of plant specialized metabolites with medical importance despite their structural simplicity compared with the modular type I and II PKS systems. The type III PKSs use homodimeric proteins to construct the molecular scaffolds of plant polyketides by iterative condensations of starter and extender CoA thioesters. Ever since the structure of chalcone synthase (CHS) was disclosed in 1999, crystallographic and mutational studies of the type III PKSs have explored the intimate structural features of these enzyme reactions, revealing that seemingly minor alterations in the active site can drastically change the catalytic functions and product profiles. New structures described in this review further build on this knowledge,

SUBMITTER: Morita H 

PROVIDER: S-EPMC6791334 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature