Prospective study of gestational diabetes and fatty liver scores 9 to 16 years after pregnancy.

ABSTRACT:

Background

Women with gestational diabetes mellitus (GDM) may be at an increased risk of liver complications because chronic hyperglycemia is a risk factor for liver fat accumulation and potential liver dysfunction. Large prospective studies examining liver fat accumulation following a GDM pregnancy are lacking.

Methods

The Diabetes & Women's Health Study (2012-2014) examined the association between GDM and subsequent fatty liver scores among 607 women with and 619 women without GDM in the Danish National Birth Cohort. Nine to 16 years postpartum, a clinical examination was performed, with measurement of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase, from which fatty liver scoring indices were calculated to assess liver fat scor

SUBMITTER: Donnelly SR 

PROVIDER: S-EPMC6791726 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature