Absorption and Safety of Topically Applied Timolol for Treatment of Chronic Cutaneous Wounds.

ABSTRACT: Objective: There are no safety or absorption studies to guide topical timolol therapy for treatment of chronic wounds. This study was undertaken to address this gap. Approach: A prospective, observational, cross-sectional comparative study of timolol plasma levels in patients after topical administration to a chronic wound, compared with levels in patients after timolol ocular administration for the indication of glaucoma. Results: There was no statistically significant difference in the average plasma level of timolol in wound as compared with glaucoma patients. No bradycardia or wheezing was observed after administration. Innovation: We determined the single time point concentration of timolol in plasma 1 h after application of timolol 0.5% gel-forming solution to debrided chronic wounds

SUBMITTER: Gallegos AC 

PROVIDER: S-EPMC6798797 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature