The Association between the Apolipoprotein E Gene Polymorphism and All-cause Mortality in the Korean Population.

ABSTRACT:

Background

Apolipoprotein E (APOE) gene polymorphism is associated with neurodegenerative and cardiovascular diseases. Although the effects of the gene differ by ethnic group, few studies have examined Asians. Therefore, the association between APOE polymorphism and mortality in Koreans was evaluated in this study.

Methods

This study population included participants from the Dong-gu and Namwon Studies. APOE genotypes were categorized as E2 (E2/E2 and E2/E3), E3 (E3/E3), and E4 (E3/E4 and E4/E4). Multivariate Cox proportional hazard models were constructed using the E3 allele as a reference.

Results

In the model adjusting for study site, age, gender, and lifestyle, the hazard ratio (HR) of mortality for those with the E4 allele was 1.08 (95% confidence interval

SUBMITTER: Choi CK 

PROVIDER: S-EPMC6801224 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature