Dataset Information
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
Ontology highlight
ABSTRACT:
SUBMITTER: Gallagher CS
PROVIDER: S-EPMC6813337 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
Nature communications 20191024 1
Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P < 5 × 10<sup>-8</sup>) loci, in addition to confirming 21 previously reported loci, including multiple independent signals at 10 loci. Phenotypic stratification o ...[more]
