Ontology highlight
ABSTRACT:
SUBMITTER: Quaresma PGF
PROVIDER: S-EPMC6814575 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Quaresma Paula G F PGF Teixeira Pryscila D S PDS Furigo Isadora C IC Wasinski Frederick F Couto Gisele C GC Frazão Renata R List Edward O EO Kopchick John J JJ Donato Jose J
Molecular and cellular endocrinology 20190905
Several hypothalamic neuronal populations are directly responsive to growth hormone (GH) and central GH action regulates glucose and energy homeostasis. However, the potential role of GH signaling in proopiomelanocortin (POMC) neurons has not been studied yet. Thus, we investigated whether POMC neurons are responsive to GH and if ablation of GH receptor (GHR) or STAT5 in POMC cells leads to metabolic imbalances. Approximately 60% of POMC neurons of the arcuate nucleus exhibited STAT5 phosphoryla ...[more]