Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites.

ABSTRACT: Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must navigate the host skin and vasculature to infect the liver. This journey requires distinct proteomes. Here, we report the dynamic transcriptomes and proteomes of both oocyst sporozoites and salivary gland sporozoites in both rodent-infectious Plasmodium yoelii parasites and human-infectious Plasmodium falciparum parasites. The data robustly define mRNAs and proteins that are upregulated in oocyst sporozoites (UOS) or upregulated in infectious sporozoites (UIS) within the salivary glands, including many that are essential for sporozoite functions in the vector and host. Moreover, we find that malaria parasites use two overlapping, extensive, and independent programs of translational repression across sporoz

SUBMITTER: Lindner SE 

PROVIDER: S-EPMC6823429 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature