Dataset Information

Effect of diabetes mellitus on risk of latent TB infection in a high TB incidence area: a community-based study in Taiwan.

ABSTRACT:

Objective

To investigate the association between diabetes and latent tuberculosis infections (LTBI) in high TB incidence areas.

Design

Community-based comparison study.

Setting

Outpatient diabetes clinics at 4 hospitals and 13 health centres in urban and rural townships. A community-based screening programme was used to recruit non-diabetic participants.

Participants

A total of 2948 patients with diabetes aged older than 40 years were recruited, and 453 non-diabetic participants from the community were enrolled.

Primary and secondary outcome measures

The interferon-gamma release assay (IGRA) and the tuberculin skin test were used to detect LTBI. The IGRA result was used as a surrogate of LTBI in logistic regression analysis.

Results

Diabetes was significantly associated with LTBI (adjusted OR (aOR)=1.59; 95% CI 1.11 to 2.28) and age correlated positively with LTBI. Many subjects with diabetes also had additional risk factors (current smokers (aOR=1.28; 95% CI 0.95 to 1.71), comorbid chronic kidney disease (aOR=1.26; 95% CI 1.03 to 1.55) and history of TB (aOR=2.08; 95% CI 1.19 to 3.63)). The presence of BCG scar was protective (aOR=0.66; 95% CI 0.51 to 0.85). Duration of diabetes and poor glycaemic control were unrelated to the risk of LTBI.

Conclusion

There was a moderately increased risk of LTBI in patients with diabetes from this high TB incidence area. This finding suggests LTBI screening for the diabetics be combined with other risk factors and comorbidities of TB to better identify high-risk groups and improve the efficacy of targeted screening for LTBI.

SUBMITTER: Lin CH

PROVIDER: S-EPMC6830704 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Publications

Effect of diabetes mellitus on risk of latent TB infection in a high TB incidence area: a community-based study in Taiwan.

Lin Ching-Hsiung CH Kuo Shu-Chen SC Hsieh Ming-Chia MC Ho Shang-Yun SY Su Ih-Jen IJ Lin Sheng-Hao SH Chi Chia-Yu CY Su Shih-Li SL Liao Chiung-Ying CY Chen Yee-Chun YC Hsu Shang-Ren SR Huang Yuan-Chun YC Tseng Fan-Chen FC Wang Shu Yi SY Dou Horng Yunn HY Lin Shi-Dou SD Lin Jen-Shiou JS Tu Shih-Te ST Yeh Yen-Po YP

BMJ open 20191028 10

<h4>Objective</h4>To investigate the association between diabetes and latent tuberculosis infections (LTBI) in high TB incidence areas.<h4>Design</h4>Community-based comparison study.<h4>Setting</h4>Outpatient diabetes clinics at 4 hospitals and 13 health centres in urban and rural townships. A community-based screening programme was used to recruit non-diabetic participants.<h4>Participants</h4>A total of 2948 patients with diabetes aged older than 40 years were recruited, and 453 non-diabetic ...[more]

PMID: 31662365

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Dataset Information

Effect of diabetes mellitus on risk of latent TB infection in a high TB incidence area: a community-based study in Taiwan.

Objective

Design

Setting

Participants

Primary and secondary outcome measures

Results

Conclusion

Publications

Effect of diabetes mellitus on risk of latent TB infection in a high TB incidence area: a community-based study in Taiwan.

Similar Datasets

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