Estimated Glomerular Filtration Rate Decline and Incident Frailty in Older Adults.

ABSTRACT: BACKGROUND AND OBJECTIVES:Low eGFR is known to be associated with frailty, but the association between the longitudinal decline of eGFR and incident frailty in older persons remains to be determined. The objective of this study was to investigate whether a fast decline on eGFR would be associated with incident frailty. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS:Community dwellers, aged ≥70, were included in this secondary analysis of the 5-year Multidomain Alzheimer Preventive Trial (MAPT). eGFR was calculated using CKD-Epidemiology Collaboration equation at baseline and at 6, 12, and 24 months. The lowest quartile of eGFR slope (-4.1 ml/min per 1.73 m2 per yr) defined a fast decline. The frailty phenotype (unintentional weight loss, exhaustion, low physical activity, slow gait, low han

SUBMITTER: Guerville F 

PROVIDER: S-EPMC6832058 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature