Determinants of arsenic methylation efficiency and urinary arsenic level in pregnant women in Bangladesh.

ABSTRACT:

Background

Prenatal inorganic arsenic (iAs) exposure is associated with pregnancy outcomes. Maternal capabilities of arsenic biotransformation and elimination may influence the susceptibility of arsenic toxicity. Therefore, we examined the determinants of arsenic metabolism of pregnant women in Bangladesh who are exposed to high levels of arsenic.

Methods

In a prospective birth cohort, we followed 1613 pregnant women in Bangladesh and collected urine samples at two prenatal visits: one at 4-16 weeks, and the second at 21-37 weeks of pregnancy. We measured major arsenic species in urine, including iAs (iAs%) and methylated forms. The proportions of each species over the sum of all arsenic species were used as biomarkers of arsenic methylation efficiency. We examined the diffe

SUBMITTER: Gao S 

PROVIDER: S-EPMC6833186 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature