Role of angiocrine signals in bone development, homeostasis and disease.
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ABSTRACT:
SUBMITTER: Sivan U
PROVIDER: S-EPMC6833221 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Role of angiocrine signals in bone development, homeostasis and disease.
Sivan Unnikrishnan U De Angelis Jessica J Kusumbe Anjali P AP
Open biology 20191002 10
Skeletal vasculature plays a central role in the maintenance of microenvironments for osteogenesis and haematopoiesis. In addition to supplying oxygen and nutrients, vasculature provides a number of inductive factors termed as angiocrine signals. Blood vessels drive recruitment of osteoblast precursors and bone formation during development. Angiogenesis is indispensable for bone repair and regeneration. Dysregulation of the angiocrine crosstalk is a hallmark of ageing and pathobiological conditi ...[more]
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