Chromatin dynamics enable transcriptional rhythms in the cnidarian Nematostella vectensis.

ABSTRACT: In animals, circadian rhythms are driven by oscillations in transcription, translation, and proteasomal degradation of highly conserved genes, resulting in diel cycles in the expression of numerous clock-regulated genes. Transcription is largely regulated through the binding of transcription factors to cis-regulatory elements within accessible regions of the chromatin. Chromatin remodeling is linked to circadian regulation in mammals, but it is unknown whether cycles in chromatin accessibility are a general feature of clock-regulated genes throughout evolution. To assess this, we applied an ATAC-seq approach using Nematostella vectensis, grown under two separate light regimes (light:dark (LD) and constant darkness (DD)). Based on previously identified N. vectensis circadian genes, our resu

SUBMITTER: Weizman EN 

PROVIDER: S-EPMC6834241 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature