A novel non-invasive method to detect excessively high respiratory effort and dynamic transpulmonary driving pressure during mechanical ventilation.

ABSTRACT:

Background

Excessive respiratory muscle effort during mechanical ventilation may cause patient self-inflicted lung injury and load-induced diaphragm myotrauma, but there are no non-invasive methods to reliably detect elevated transpulmonary driving pressure and elevated respiratory muscle effort during assisted ventilation. We hypothesized that the swing in airway pressure generated by respiratory muscle effort under assisted ventilation when the airway is briefly occluded (ΔP_occ) could be used as a highly feasible non-invasive technique to screen for these conditions.

Methods

Respiratory muscle pressure (P_mus), dynamic transpulmonary driving pressure (ΔP_L,dyn, the difference between peak and end-expiratory transpulmonary pressure), and ΔP

SUBMITTER: Bertoni M 

PROVIDER: S-EPMC6836358 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature