Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC6836726 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Cancer cell 20181101 5
Pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance and immunotherapeutic resistance. We discovered upregulation of receptor-interacting serine/threonine protein kinase 1 (RIP1) in tumor-associated macrophages (TAMs) in PDA. To study its role in oncogenic progression, we developed a selective small-molecule RIP1 inhibitor with high in vivo exposure. Targeting RIP1 reprogrammed TAMs toward an MHCII<sup>hi</sup>TNFα<sup>+</sup>IFNγ<sup>+</sup> immunogenic phenotype in a STA ...[more]