Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial.

ABSTRACT:

Objective

To investigate the clinical efficacy of a multi-strain probiotic product on bowel habits and microbial profile in participants with functional constipation.

Methods

This was a randomized, double-blind, placebo-controlled and parallel-arm study. Altogether 94 otherwise healthy adults aged 18 to 65 years with symptoms of functional constipation were randomized as part of the intention-to-treat population. The participants received a placebo or the probiotic product (1.5 × 10¹⁰ CFU/day), consisting of Lactobacillus acidophilus DDS-1, Bifidobacterium animalis subsp. lactis UABla-12, Bifidobacterium longum UABl-14 and Bifidobacterium bifidum UABb-10 over 4 weeks. Outcomes included the patient assessment of constipation-symptom (PAC-SYM) questionnaire, stool f

SUBMITTER: Martoni CJ 

PROVIDER: S-EPMC6851827 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature