A harmonized longitudinal biomarkers and cognition database for assessing the natural history of preclinical Alzheimer's disease from young adulthood and for designing prevention trials.

ABSTRACT:

Introduction

Large longitudinal biomarkers database focusing on middle age is needed for Alzheimer's disease (AD) prevention.

Methods

Data for cerebrospinal fluid analytes, molecular imaging of cerebral fibrillar β-amyloid with positron emission tomography, magnetic resonance imaging-based brain structures, and clinical/cognitive outcomes were harmonized across eight AD biomarker studies. Statistical power was estimated.

Results

The harmonized database included 7779 participants with clinical/cognitive data: 3542 were 18∼65 years at the baseline, 5865 had longitudinal cognitive data for a median of 4.7 years, 2473 participated in the cerebrospinal fluid studies (906 had longitudinal data), 2496 participated in the magnetic resonance imaging studies (1283 had longitudi

SUBMITTER: Xiong C 

PROVIDER: S-EPMC6874758 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature