Race-ethnic differences in the associations of maternal lipid trait genetic risk scores with longitudinal fetal growth.

ABSTRACT:

Background

Fetal growth, an important predictor of cardiometabolic diseases in adults, is influenced by maternal and fetal genetic and environmental factors.

Objective

We investigated the association between maternal lipid genetic risk score (GRS) and fetal growth among 4 US racial-ethnic populations (Whites, Blacks, Hispanics, and Asians).

Methods

We extracted genotype data for 2008 pregnant women recruited in the National Institute of Child Health and Human Development Fetal Growth Studies-Singleton cohort with up to 6 standardized ultrasound examinations. GRS was calculated using 240 single-nucleotide polymorphisms previously associated with higher total cholesterol (GRS_TChol), low-density lipoprotein cholesterol (GRS_LDLc), and triglycerides (

SUBMITTER: Ouidir M 

PROVIDER: S-EPMC6885118 | biostudies-literature | 2019 Sep - Oct

REPOSITORIES: biostudies-literature