CNVScope: Visually Exploring Copy Number Aberrations in Cancer Genomes.

ABSTRACT:

Motivation

DNA copy number (CN) data are a fast-growing source of information used in basic and translational cancer research. Most CN segmentation data are presented without regard to the relationship between chromosomal regions. We offer both a toolkit to help scientists without programming experience visually explore the CN interactome and a package that constructs CN interactomes from publicly available data sets.

Results

The CNVScope visualization, based on a publicly available neuroblastoma CN data set, clearly displays a distinct CN interaction in the region of the MYCN, a canonical frequent amplicon target in this cancer. Exploration of the data rapidly identified cis and trans events, including a strong anticorrelation between 11q loss and17q ga

SUBMITTER: Dalgleish JL 

PROVIDER: S-EPMC6887803 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature