Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses.

ABSTRACT: Cytosolic nucleic acid-sensing pathways can be triggered to enhance immune response to cancer. In this study, we tested the antitumor activity of a unique RIG-I agonist, stem loop RNA (SLR) 14. In the immunogenic tumor models, we observed significant tumor growth delay and an extended survival in SLR14-treated mice. SLR14 also greatly improved antitumor efficacy of anti-PD1 antibody over single-agent treatment. SLR14 was mainly taken up by CD11b⁺ myeloid cells in the tumor microenvironment, and many genes associated with immune defense were significantly up-regulated after treatment, accompanied by increase in the number of CD8⁺ T lymphocytes, NK cells, and CD11b⁺ cells in SLR14-treated tumors. Strikingly, SLR14 dramatically inhibited nonimmunogenic B16 tum

SUBMITTER: Jiang X 

PROVIDER: S-EPMC6888973 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature