Ontology highlight
ABSTRACT:
SUBMITTER: Cowan JE
PROVIDER: S-EPMC6889275 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Nature communications 20191202 1
Interactions between thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but molecular insights on TEC and thymus homeostasis are still lacking. Here we identify distinct transcriptional programs of TEC that account for their age-specific properties, including proliferation rates, engraftability and function. Further analyses identify Myc as a regulator of fetal thymus development to support the rapid increase of thymus size during fetal life. Enforced M ...[more]