Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair.

ABSTRACT: Mucosal wound repair is coordinated by dynamic crosstalk between endogenous and exogenous mediators and specific receptors on epithelial cells and infiltrating immune cells. One class of such receptor-ligand pairs involves formyl peptide receptors (FPRs) that have been shown to influence inflammatory response and repair. Here we explored the role of murine Fpr2/3, an ortholog of human FPR2/receptor for lipoxin A4 (ALX), in orchestrating intestinal mucosal repair. Compared with wild-type (WT) mice, Fpr2/3^-/- mice exhibited delayed recovery from acute experimental colitis and perturbed repair after biopsy-induced colonic mucosal injury. Decreased numbers of infiltrating monocytes were observed in healing wounds from Fpr2/3^-/- mice compared with WT animals.

SUBMITTER: Birkl D 

PROVIDER: S-EPMC6894067 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature