Unraveling the action mechanism of polygonum cuspidatum by a network pharmacology approach.

ABSTRACT: As a popular Chinese herbal medicine (CHM), polygonum cuspidatum is widely used to treat various diseases in China. However, its biological function and action mechanism have yet to be systematically explored. In the present study, we first identified 14 potential active ingredients of polygonum cuspidatum using the TCMSP server and then conducted an in silico target prediction for these ingredients using PharmMapper. The subsequent KEGG pathway enrichment analysis of the 57 identified potential targets revealed that they were closely associated with cancer and gynecological disorders. Furthermore, a protein-protein interaction network of these targets was constructed using STRING and Cytoscape, through which 11 core targets were excavated according to degree, a key topological parameter.

SUBMITTER: Pan B 

PROVIDER: S-EPMC6895524 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature