Longitudinal molecular trajectories of diffuse glioma in adults.

ABSTRACT: The evolutionary processes that drive universal therapeutic resistance in adult patients with diffuse glioma remain unclear^1,2. Here we analysed temporally separated DNA-sequencing data and matched clinical annotation from 222 adult patients with glioma. By analysing mutations and copy numbers across the three major subtypes of diffuse glioma, we found that driver genes detected at the initial stage of disease were retained at recurrence, whereas there was little evidence of recurrence-specific gene alterations. Treatment with alkylating agents resulted in a hypermutator phenotype at different rates across the glioma subtypes, and hypermutation was not associated with differences in overall survival. Acquired aneuploidy was frequently detected in recurrent gliomas and was charac

SUBMITTER: Barthel FP 

PROVIDER: S-EPMC6897368 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature