Gene-level genome-wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population.

ABSTRACT:

Background

Evidence suggests that liability for suicide behavior is heritable; additionally, suicide has been partly related to other psychiatric disorders. Nevertheless, most of the information reported so far address Caucasian and Asian individuals. Hence, our aim was to conduct a gene-level association study in Mexican psychiatric individuals diagnosed with suicide attempt.

Methods

We recruited 192 individuals from two clinical centers in Mexico. All participants were born in Mexico and had Mexican parents and grandparents. Direct genotyping was performed using the commercial platform Infinium PsychArray BeadChip. A p-value lower than 1e-05 was considered as gene-level significant and a p-value lower than 1e-04 was considered as gene-level nominal significant.

Results<

SUBMITTER: Gonzalez-Castro TB 

PROVIDER: S-EPMC6900393 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature