Validation of T2- and diffusion-weighted magnetic resonance imaging for mapping intra-prostatic tumour prior to focal boost dose-escalation using intensity-modulated radiotherapy (IMRT).

ABSTRACT:

Background and purpose

To assess the diagnostic accuracy and inter-observer agreement of T2-weighted (T2W) and diffusion-weighted (DW) magnetic resonance imaging (MRI) for mapping intra-prostatic tumour lesions (IPLs) for the purpose of focal dose-escalation in prostate cancer radiotherapy.

Materials and methods

Twenty-six men selected for radical treatment with radiotherapy were recruited prospectively and underwent pre-treatment T2W+DW-MRI and 5 mm spaced transperineal template-guided mapping prostate biopsies (TTMPB). A 'traffic-light' system was used to score both data sets. Radiologically suspicious lesions measuring ≥0.5 cm³ were classified as red; suspicious lesions 0.2-0.5 cm³ or larger lesions equivocal for tumour were classified as amber. The

SUBMITTER: Alexander EJ 

PROVIDER: S-EPMC6908966 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature