Ontology highlight
ABSTRACT:
SUBMITTER: Allali-Hassani A
PROVIDER: S-EPMC6917776 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Nature communications 20191217 1
PRDM9 is a PR domain containing protein which trimethylates histone 3 on lysine 4 and 36. Its normal expression is restricted to germ cells and attenuation of its activity results in altered meiotic gene transcription, impairment of double-stranded breaks and pairing between homologous chromosomes. There is growing evidence for a role of aberrant expression of PRDM9 in oncogenesis and genome instability. Here we report the discovery of MRK-740, a potent (IC<sub>50</sub>: 80 ± 16 nM), selective a ...[more]